Our main goal is to understand the circuits that process information coming into the hippocampus using an electrophysiological approach. We are analyzing responses obtained from paired recordings of granule cells and CA3 pyramidal cells, or from interneurons. We are also examining the effects of entorhinal input on hippocampal circuit dynamics. Our experiments involve recording membrane currents from neurons in slice cultures using the patch clamp method and imaging of intracellular calcium signals.
A further goal is the characterization of novel transduction mechanisms that target ion channels. We are studying how metabotropic glutamate receptors activate Src kinase to modulate the properties of NMDA receptors and TRP channels.