Branco Weiss Fellow - Anna-Sophia Wahl

Master Position

We are currently looking for a talented Masterstudent investigating vascular dementia to understand memory formation and degeneration on a cellular resolution level.

detailed project description (PDF, 7 KB)

Research summary

A prerequisite for the recovery of impaired brain function is the capacity of the central nervous system to induce plastic rewiring and reorganization processes after CNS injury. However, where and how neuronal connections regrow, which neuronal circuits reorganize, stabilize or disintegrate and how neuronal remodeling contributes to the functional outcome is not well understood. My work aims at understanding fundamental principles of neuronal circuit rewiring and individual neuronal recoding as intrinsic repair mechanisms of the brain recruiting intact structures to regain lost or impaired functions. The examination of causal relationships between neuronal rewiring and recovery of distinct sensorimotor and cognitive features opens up new possibilities for targeted novel therapeutic approaches or optimized rehabilitative strategies in stroke and vascular dementia.

Group Members

Position

Name

Photo

Room

Phone

E-Mail

PhD student

Hendrik Heiser

 

55H30

044 63 53338

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PhD student

Jithin Nambiar

 

55H30

044 63 53338

coming soon

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Key Publications

Wahl AS, Büchler U, Brändli A, Brattoli B, Musall S, Kasper H, Ineichen BV, Helmchen F, Ommer B, Schwab ME (2017) Optogenetic stimulation of the intact corticospinal tract after stroke restores motor control through regionalized functional circuit formation. Nature Communications 8(1):1187. doi: 10.1038/s41467-017-01090-6.

Wahl AS, Omlor W, Rubio JC, Chen JL, Zheng H, Schröter A, Gullo M, Weinmann O, Kobayashi K, Helmchen F, Ommer B, Schwab ME (2014) Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke. Science 344(6189):1250-5. doi: 10.1126/science.1253050.

Wahl AS, Schwab ME (2014) Finding an optimal rehabilitation paradigm after stroke: enhancing fiber growth and training of the brain at the right moment. Front Hum Neurosci. 7:911. doi: 10.3389/fnhum.2013.00911.