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Jawaid, A., Kunzi, M., Mansoor, M., Khan, Z.Y., Abid, A., Taha, M., Rigotti, S., Thumfart, K., Faisal, S., Chughtai, O., and Mansuy, I.M. (2020). Distinct microRNA signature in human serum and germline after childhood trauma. medRxiv

Lazar-Contes, I., Tanwar, KT, Germain, P.L., Gaur, N. and Mansuy, I.M. (2020).Transcriptome and epigenome characterization of mouse spermatogonial cells reveals distinct chromatin regulatory landscapes in postnatal and adult testis. bioRxiv


La Plante et al. (2023). exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers. Cell Genomics

Ibañez, V., Bohlen, L. Manuella, F., Mansuy, I.M., Helmchen, F. and Wahl, A.S. (2023). EXPLORE: A novel deep learning-based analysis method for exploration behaviour in object recognition tests. Sci. Rep. 13,4249

Arzate-Mejia, R.G., Mansuy, I.M. Remembering through the genome: the role of chromatin states in brain functions and diseases. Transl. Psychiatry 13, 122 (2023).

Thumfart K.M., Mansuy I.M. What are Sertoli cells? Historical, methodological, and functional aspects. Andrology.

Calestrm N., Jenssen T., Ostermann G., Mansuy I.M. and Besson J. Se donner toutes les chances. Eds Albin Michel. 8 March 2023. ISBN10:2226480544. Book


Boscardin C., Manuella, F. and Mansuy, I.M. (2022). Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice. Env. Epigen. Volume 8, Issue 1, 2022, dvac024

Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M. (2022). Long-term effects of early postnatal stress on Sertoli cells functions. Front. Genet. 13:1024805.

Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M. (2022). Epigenetics of childhood trauma: Long-term sequelae and potential for treatment. Neurosci Biobehav Rev. 132:1049-66.

Dimitriu, M, Lazar-Contes, I., Roszkowski, M.  and Mansuy, I.M. (2022). Single-cell multiomics techniques: from conception to applications. Front. Cell. Dev. Biol. 10:854317.


Roszkowski, M and Mansuy, I.M. (2021). High efficiency RNA extraction from sperm cells using guanidinium thiocyanate supplemented with tris(2-carboxyethyl)phosphine. Front. Cell. Dev. Biol.

Jawaid, A and Mansuy, I.M. Transmission of the effects of trauma across generations: Biological mechanisms and implications for individuals and the society. Neuroscience and PeaceBuilding, United States Institute of Peace.

Mariani, N., Borsini, A., Cecil, C.A.M., Felix, J.F., Sebert, S., Cattaneo, A., Walton, E., Milaneschi, Y., Cochrane, G., Amid, C., Rajan, J., Giacobbe, J., Sanz, Y., Agustí, A., Sorg, T., Herault, Y., Miettunen, J., Parmar, P., Cattane, N., Jaddoe, V., Lötjönen, J., Buisan, C., González Ballester, M.A., Piella, G., Gelpi, J.L., Lamers, F., Penninx, B., Tiemeier, H., von Tottleben, M., Thiel, R., Heil, K.F., Järvelin, M.R., Pariante, C., Mansuy, I.M., Lekadir, Karim. Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project.PLoS One. 2021 Jan 21;16(1):e0245475.

Grandjean, J., Corcoba, A., Kahn, M.C., Upton, A.L., Deneris, E.S., Seifritz, E. Helmchen, F., Mansuy, I.M., Mann, E.O., Rudin, M., Saab, B.J. (2021). A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine. Nat. Commun. 12:1168-77.


van Steenwyk G., Gapp, K., Jawaid, A., Germain, P.-L., Manuella, F., Tanwar D.T., Zamboni N., Gaur, N., Thumfart, K., Efimova, A., Miska, E.A. and Mansuy, I.M. (2020). Involvement of circulating factors in the transmission of paternal experiences through the germline. EMBO J. e104579.

Gapp, K., van Steenwyk, G., Germain, P.-L., Matsushima, W., Rudolph, K., Manuella, F., Roszkowski, M., Vernaz, G., Gosh, T., Pelczar, P., Mansuy, I.M.* and Miska, E. A.* (2020). Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma. Mol. Psych.  25:2162-74.

Würtz-Kozak, K., Roszkowski, M., Cambria, E., Block, A., Kuhn, G.A., Abele, T., Hitzl, W., Driesslein, D., Müller, R., Rapp, M.A., Mansuy, I.M., Peters, E.M.J and Wippert, P.M. (2020). Effects of early life stress on bone homeostasis in mice and humans. Int. J. Mol. Sci. 21:6634-40.

Arzate-Mejía, R.G., Lottenbach, Z., Schindler, V., Jawaid, A. and Mansuy, I.M. (2020). Long term impact of social isolation and molecular underpinnings. Front. Genet. 11:589621.

Jawaid, A., Jehle, K, and Mansuy, I.M. (2020). Impact of parental exposure on offspring health in humans. Trends in Genet.Epub 2020 Nov 11. PMID: 33189388

Engmann O and Mansuy IM (2020). Stress and its effects across generations. Stress Resilience: Molecular and Behavioral Aspects. Edited by Alon Chen. San Diego: Elsevier Inc./Academic Press. pp269-283. link

van Steenwyk and Mansuy, I.M. (2020). Epigenetics and the impact of early life stress across generations. Nutritional Epigenomics. Handbook of Stress: Stress, Genetics, Epigenetics, Genomics. Volume 4. Elsevier. Edited by George Fink. In press. book

Mansuy, I.M., Gurret, J.M. Lelief, A. (2020) “Wir können unsere Gene steuern”. Berlin Verlag. August 31 2020. ISBN-10 : 3827014115 book


Jawaid A, Woldemichael BT, Kremer EA, Laferriere F, Gaur N, Afroz T, Polymenidou M and Mansuy IM (2019). Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis. Mol Neurobiol., 56:3451-3462. abstract

Jawaid A and Mansuy IM (2019). Inter and transgenerational inheritance of behavioral phenotypes. Curr Opin Behavioral Sci., 25:96-101. article

van Steenwyk G, Jawaid A and Mansuy IM (2019). Epigenetic inheritance of metabolic signals. Nutritional Epigenomics, 11:167-190. abstract

Wippert PM, Block A, Mansuy IM, Peters EMJ, Rose M, Rapp MA, Huppertz A, Wuertz-Kozak K (2019). Alterations in bone homeostasis and microstructure related to depression and allostatic load. Psychotherapy Psychosomatics. 88:383-85. link

Maciel E and Mansuy IM (2019). Extracellular vesicles and their miRNA cargo: A means of communication between soma and germline in the mammalian reproductive system. Chimia, 73:356-61. abstract

Book: Mansuy, I.M., Gurret, J.M. Lelief, A. (2019). Reprenez le contrôle de vos gènes: Améliorez votre vie et celles de vos descendant avec l'épigénétique. Editions Larousse, ISBN 2035956218. link


Gapp K, van Steenwyk G, Germain P-L, Matsushima W, Rudolph K, Manuella F, Roszkowski M, Vernaz G, Gosh T, Pelczar P, Mansuy IM and Miska E (2018). Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma. Mol Psych. article

van Steenwyk G, Roszkowski M, Manuella F, Franklin T and Mansuy IM (2018). Transgenerational inheritance of behavioral and metabolic effects of paternal exposure to traumatic stress in early postnatal life: Evidence in the 4th generation. Environm Epigenetics, 4:023. article

von Ziegler L, Selevsek N, Tweedie-Cullen RY, Kremer EA and Mansuy IM (2018). Subregion-specific proteomic signature in the hippocampus for recognition processes in adult mice. Cell Reports, 22:3362-3374. article

Kremer EA, Gaur N, Lee MA, Engmann O, Bohacek J and Mansuy IM (2018). Interplay between TETs and microRNAs in the adult brain for memory formation. Scientific Reports, 8:1678. article

Bohacek J, Weber-Stadlbauer U and Mansuy IM (2018). Paternal experience impacts cognitive function in offspring: a pre-existing concept. Mol Psychiatr., 23:794-795. abstract

Jawaid A, Roszkowski M, Mansuy IM (2018). Chapter Twelve: Transgenerational epigenetics of traumatic stress. Prog Mol Biol Transl Sci., 158:273-298. abstract

Bohacek J, Engmann O, Germain PL, Schelbert S, Mansuy IM (2018). Transgenerational epigenetic inheritance: from biology to society-Summary Latsis Symposium Aug 28-30, 2017, Zürich, Switzerland. Environ Epigenet., 4:12. article

Mansuy IM (2018). Meeting Announcement: 2nd Symposium ‘Epigenetic Inheritance: Impact for Biology and Society’26–28 August 2019, ETH Zurich, Switzerland. Environmental Epigenetics, 4. article


Bohacek J and Mansuy IM (2017). A guide to designing germline-dependent epigenetic inheritance experiments in mammals. Nat Methods, 14:243-249. abstract

Razoux F, Russig R, Baltes C, Mueggler T, Dikaiou K, Rudin M and Mansuy IM (2017). Transgenerational disruption of functional 5-HT1AR-induced connectivity in the adult mouse brain by traumatic stress in early life. Mol Psychiatr., 22:519-526. abstract

Woldemichael BT and Mansuy IM (2017). The epigenetics basis of memory. Learning and Memory: A Comprehensive Reference. 2nd Edition. Edited by John H. Byrne. Elsevier. ISBN: 9780128051597. link

Jawaid A, Kremer E and Mansuy IM (2017). Epigenetics of brain disorders. Handbook of Epigenetics. The New Molecular and Medical Genetics. 2nd Edition. Edited by Trygve Tollefsbol. Elsevier. ISBN: 9780128053881. link

Weber-Stadlbauer U, Richetto J, Labouesse MA, Bohacek J, Mansuy IM and Meyer U (2017). Transgenerational transmission and modification of pathological traits induced by prenatal immune activation. Mol Psychiatr., 22:102–112.abstract

Gapp K, Corcoba A, van Steenwyk G, Mansuy, IM, Duarte JM (2017). Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring. J Cereb Blood Flow Metab., 37:2423-2432. abstract

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy IM, Jeltsch A, Akbarian S and Nestler EJ (2017). Cocaine-induced chromatin modifications associate with increased expression and three-dimensional looping of Auts2. Biol Psych., 82:794-805. abstract

Mansuy IM and Salthun-Lassalle B (2017). La vie in utéro rend parfois violent. Cerveau & Psycho., 91:12-13. article


Woldemichael BT, Jawaid A, Kremer EA, Gaur N, Krol J, Marchais A and Mansuy IM (2016). The microRNAs cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner. Nat Commun., 7:12594. article

Gapp K, Bohacek J, Grossmann J, Brunner AM, Manuella F, Nanni P, and Mansuy IM (2016). Potential of environmental enrichment to prevent transgenerational effects of paternal trauma. Neuropsychopharmacol., 41:2749-58.abstract

Bohacek J, von Werdt S, Mansuy IM (2016). Probing the germline-dependence of non-genetic inheritance using artificial insemination in mice. Environ Epigenetics, 2:15-25.abstract

Heitz F, Farinelli M, Mohanna S, Kahn M, Duning K, Frey M, Pavenstädt H and Mansuy IM (2016). The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain. Neurobiol Learn Memory, 135:100-114.abstract

Woldemichael BT, Mansuy IM (2016). Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics. Biochem Pharmacol., 104:1-7. abstract

Bohacek J  and Mansuy IM (2016). Epigenetic risk factors for diseases: A transgenerational perspective. In epigenetics and human health. Epigenetics and Neuroendocrinology. Edited by Spengler and Binder. Springer, Pp 79-119. link

Roszkowski M, Manuella F, von Ziegler L, Durán-Pacheco G, Moreau J-L, Mansuy IM and Bohacek J, (2016). Rapid stress-induced transcriptiomic changes in the brain depend on betaadrenergic signaling. Neuropharmacol., 107:329-38. abstract

Kleine Borgmann FK, Graeff J, Mansuy IM, Toni N, and Jessberger S (2016). Enhanced plasticity of mature granule cells reduces survival of newborn neurons in the adult mouse hippocampus. Matters. article

Toth M, Flandreau EI, Deslauriers J, Geyer MA, Mansuy IM, Merlo Pich E, and Risbrough VB (2016). Overexpression of forebrain CRH during early life increases trauma susceptibility in adulthood. Neuropsychopharmacol., 41:1681-90. abstract


Bohacek J, Farinelli L, Mirante O, Steiner G, Gapp K, Coiret G, Eberling M, Durán-Pacheco G, Iniguez AL, Manuella M, Moreau JL, Mansuy IM (2015). Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress. Mol Psychiatr., 20:621-631. abstract

Bohacek J, Manuella F, Roszkowski M, Mansuy IM (2015). Hippocampal gene expression induced by cold swim stress depends on sex and handling. Psychoneuroendochrino., 52:1-12.abstract

Bohacek J, Mansuy IM (2015). Molecular insights into transgenerational non-genetic inheritance of acquired behaviours. Nat Rev Genet., 16:641-652. abstract

Diester I, Hefti F, Mansuy IM, Pascual-Leone A, Robbins TW, Rubin LL, Sawa A, Wernig M, Dölen G, Hyman SE, Mucke L, Nikolich N, Sommer B (2015). Bridging the gap between patients and models. From “Translational Neuroscience: Toward New Therapies”. Karoly Nikolich and Steven E. Hyman, eds. 2015. Strüngmann Forum Reports, vol. 17, series ed. J. Lupp. Cambridge, MA: MIT press (book chapter; ISBN 978-0-262-02986-5).link

Dölen G, Malenka RC, Perlmutter J, Brose N, Frackowiak R, Cuthbert BN, Diester I, Mansuy IM, Kroker KS, Boeckers TM, Pascual-Leone A, Guoping F (2015). Pathophysiological Toolkit: Genes to Circuits. From “Translational Neuroscience: Toward New Therapies”. Karoly Nikolich and Steven E. Hyman, eds. 2015. Strüngmann Forum Reports, vol. 17, series ed. J. Lupp. Cambridge, MA: MIT press (book chapter; ISBN 978-0-262-02986-5).link


Gapp K, Jawaid A, Sarkies P, Bohacek J, Pelczar P, Prados J, Farinelli L, Miska E, Mansuy IM (2014). Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nature Neurosci., 17:667-669.pdf

Gapp K, Soldado-Magraner S, Alvarez-Sánchez M, Bohacek J, Vernaz G, Shu H, Franklin TB, Wolfer D, Mansuy IM (2014). Early life stress in fathers improves behavioural flexibility in their offspring. Nature Commun., 5:5466-73.pdf

Brunner AM, Nanni P, Mansuy IM (2014). Epigenetic marking of sperm by post-translational modification of histones and protamines. Epigenetics Chromatin, 7:2-12.pdf

Heitz F, Johansson T, Baumgärtel K, Gecaj R, Pelczar P, Mansuy IM (2014). Heritable and inducible gene knockdown in astrocytes or neurons in vivo by a combined lentiviral and RNAi approach. Front Cell Neurosci., 8:62. pdf

Mirante O, Brandalise F, Bohacek J, Mansuy IM (2014). Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci., 7:1-12.article

Saab BJ, Mansuy IM (2014). Neuroepigenetics of memory formation and impairment: The role of microRNAs. Neuropharmacology, 80:61-69. article

Gapp K, von Ziegler L, Tweedie-Cullen RY, Mansuy IM (2014). Early life epigenetic programming and transmission of stress-induced traits in mammals: How and when can environmental factors influence traits and their transgenerational inheritance? BioEssays, 36:491-502. pdf

Woldemichael BT, Bohacek J, Gapp K, Mansuy IM (2014). Epigenetics of memory and plasticity. Prog Mol Biol Transl Sci., 122:305-40. abstract

Gapp K, Woldemichael BT, Bohacek J, Mansuy IM (2014). Epigenetic regulation in neurodevelopment and neurodegenerative diseases. Neuroscience, 4:264:99-111. article

Saab BJ, Mansuy IM (2014). Neurobiological disease etiology and inheritance: an epigenetic perspective. J Exp Biol., 217:94-101. (Review) pdf

Penke Z, Morice E, Veyrac A, Gros A, Chagneau C, LeBlanc P, Samson N, Baumgärtel K, Mansuy IM, Davis S, Laroche S (2014). Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory. Philos T Roy Soc B., 369:20130159.pdf

Toth M, Gresack JE, Bangasser DA, Plona Z, Valentino RJ, Flandreau EI, Mansuy IM, Merlo-Pich E, Geyer MA, Risbrough VB (2014). Forebrain-specific CRF overproduction during development is sufficient to induce enduring anxiety and startle abnormalities in adult mice. Neuropsychopharmacology. 39(6):1409-1419. pdf


Park CS, Rehrauer H, Mansuy IM (2013). Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. BMC Genomics, 14:539.pdf

Von Ziegler L, Saab BJ, Mansuy IM (2013). A simple and fast method for tissue cryohomogenization enabling multifarious molecular extraction. J Neurosci Methods, 216:137-41.article

Vizi S, Mansuy IM (2013). A cold radial maze for long-lasting spatial memory in mice. J Neurosci Methods, 213:274-81.article

Bohacek J, Gapp K, Saab BJ, Mansuy IM (2013). Transgenerational epigenetic effects on brain functions. Biol Psych., 73:313-20. article

Bohacek J, Mansuy IM (2013). Epigenetic inheritance of disease and disease risk. Neuropsychopharm Rev., 38:220-36. pdf

Mansuy, I.M. (2013). The epigenetics of brain disorders and their inheritance – Focus on cognition. European Neuropsychopharmacol. 23:S57. article

Franklin T, Mansuy IM (2013). The neural bases of emotions. Neurosciences, Edited by CG Galizia, PM Lledo. Springer Verlag Berlin, 525-52. book

Seimandi M, Seyer P, Park CS, Vandermoere F, Chanrion B, Bockaert J, Mansuy IM , Marin P (2013). Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake. J Neurosci., 33:16189-99.pdf

Razoux F, Baltes C, Mueggler T, Seuwen A, Russig H, Mansuy IM, Rudin M (2013). Functional MRI to assess alterations of functional networks in response to pharmacological or genetic manipulations of the serotonergic system in mice. Neuroimage, 74:326-36.article

Beil J, Mansuy IM, Buch T (2013). Chapter 1 - Conditional Gene targeting: A Refined Method for Genetic Studies in Neurosciences. NeuroMethods, Multidisciplinary Tools for Investigating Synaptic Plasticity. Springer Science, 81:3-41. article

Mansuy IM, Mashoodh R, Champagne F (2013). Chapter 13 - Transgenerational inheritance in mammals. In Epigenetic Regulation in the Nervous System. Edited by David Sweatt, Michael Meaney, Eric Nestler and Shahram Akbarian. Academic Press, 323-38. abstract


Graeff J, Woldemichael B, Berchtold D, Dewarat G, Mansuy IM (2012). Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation. Nat Commun., 3:991-97. pdf

Farinelli M, Heitz FD, Grewe BF, Tyagarajan SK, Helmchen F and Mansuy IM (2012). Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. PLoS ONE, 7:e34047. article

Tweedie-Cullen RY, Brunner AM, Grossmann J, Mohanna S, Sichau D, Nanni P, Panse C, Mansuy IM (2012). Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain. PLoS ONE, 7:36980. pdf

Franklin T, Saab BJ, Mansuy IM (2012). The neural mechanisms of stress resilience and vulnerability. Neuron, 75: 747-761. article

Brunner AM, Tweedie-Cullen RY, Mansuy, IM (2012). Epigenetic modifications of the neuroproteome. Proteomics, 12:2404-20. pdf

Baumgaertel K, Mansuy IM (2012). Neural functions of calcineurin in synaptic plasticity and memory. Learn Mem., 19:375-84. pdf

Tweedie-Cullen RY, Brunner AM, Mansuy IM (2012). Proteomic analysis of phosphorylation in the brain. Curr. Proteomics, 9:167-85. abstract

Franklin T. and Mansuy, I.M. (2012). Kinases and phosphatases in the epigenetic regulation of cognitive functions. Epigenomics: From chromatin biology to therapeutics. Cambridge University Press, Cambridge, UK. ISBN:9781139533997. link

Saab, B. J. and Mansuy, I.M. (2012). Epigenetics of memory: Evidence and models. Advances in Epigenetics of Lifestyle. Bentham Science Publishers. 978-1-60805-534-0, 36-69. book

Bohacek, J. and Mansuy, I.M. (2012). Epigenetic inheritance in mammals. Epigenetics, Brain and Behavior, Sassone-Corsi P, Christen Y, Eds. Heidelberg, Springer. ISBN 978-3-642-27912-6. book

Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, DeRubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joëls M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov., 11:141-168. pdf


Weiss, I.C., Franklin T., Vizi, S. and Mansuy I.M. (2011). Inheritable effect of unpredictable maternal separation on behavioral responses in mice. Frontiers in Behav. Neurosci. Feb;5(3):1-12 pdf (PDF, 2 MB)

Koshibu, K., Gräff, J., Mansuy, I.M. (2011). Nuclear protein phosphatase-1: an epigenetic regulator of fear memory and amygdala long-term potentiation. Neuroscience. Jan;173:30-36.pdf (PDF, 1 MB)

Franklin, T., Linder, N., Russig, H., Thöny, B. and Mansuy I.M. (2011). Influence of early stress on social abilities and serotonergic function across generations in mice. PLoS One. Jul;6(7):e21842.pdf (PDF, 406 KB)

Franklin T.B. and Mansuy I.M. (2011). The involvement of epigenetic defects in mental retardation. Neurobiol. Learn Mem. Jul;96(1):61-7 pdf (PDF, 163 KB)

Mueggler T., Razoux F., Russig H., Buehler A., Franklin T.B., Baltes C., Mansuy, I.M, Rudin M. (2011). Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain. Eur Neuropsychopharmacol. Apr;21(4):344-53.pdf (PDF, 821 KB)

Schmutz, I., Wendt, S., Schnell, A., Kramer, A., Mansuy, I.M., and Albrecht, U. (2011). Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PLoS One. Jun;6(6):e21325.pdf (PDF, 871 KB)

Mansuy I.M. and Mohanna S. (2011). Epigenetics and the human brain: Where nurture meets nature. Cerebrum. The Dana Foundation. pdf (PDF, 469 KB)

Tweedie-Cullen R.Y., Park C.S., Mansuy I.M. (2011) Protein Phosphatases in the Brain: Regulation, Function and Disease. In: Vidal C. (eds) Post-Translational Modifications in Health and Disease. Protein Reviews, vol 13. Springer, New York, NY pdf


Franklin, T., Russig, H., Weiss, I.C., Gräff, J., Linder, N., Michalon, A., Vizi, S. Mansuy I.M. (2010). Epigenetic Transmission of the Impact of Early Stress Across Generations. Biol. Psych. 68:408–415. pdf (PDF, 1 MB)

Gräff J, Koshibu K, Jouvenceau A, Dutar P, Mansuy I.M. (2010) Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity. Learning and Memory. 17(7):355-63 pdf (PDF, 326 KB)

Franklin T.B., and Mansuy I.M. (2010b) The prevalence of epigenetic mechanisms in the regulation of cognitive functions and behaviour. Curr. Opin. Neurobiol. 20(4):441-9.pdf (PDF, 359 KB)

Franklin T.B., and Mansuy I.M. (2010a) Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effects. Neurobiol Dis. 39(1):61-5 pdf (PDF, 165 KB)

Mansuy, IM, Koshibu, K., Graeff, J. (2010). Epigenetic regulation of cognitive functions. European Neuropsychopharmacology, 20(3):S159 link

Tweedie-Cullen, R.Y., Mansuy, I.M. (2010). Towards a better understanding of nuclear processes based on proteomics. Amino Acids. Nov;39(5):1117-30 pdf (PDF, 540 KB)

Graeff, J., Franklin T. and Mansuy, I.M. (2010). Epigénétique et mémoire. Biol. Aujourd’hui. 204:131-37 link

Charrier, C., Machado, P., Tweedie-Cullen, R.Y., Rutishauser, D., Mansuy, I.M., Triller, A. (2010). A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses. Nature Neurosci. Nov;13(11):1388-95 pdf (PDF, 1 MB)

Calella, A.M., Farinelli, M., Nuvolone, M., Mirante, O., Moos, R., Falsig, J., Mansuy, I.M., Aguzzi, A. (2010). Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med. 2(8):306-14 pdf (PDF, 405 KB)

Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm J, Mansuy I.M., Bergersen LH, Klungland A. (2010) Mitochondrial DNA Toxicity in Forebrain Neurons causes Apoptosis, Neurodegeneration and Impaired Behavior. Mol. Cell. Biol. 30(6):1357-67 pdf (PDF, 3 MB)


Koshibu, K.*, Graeff, J.*, Beullens, M., Heitz, F., Berchtold, D., Russig, H., Farinelli, M, Bollen, M and Mansuy I.M. (2009). Protein phosphatase 1 regulates the histone code for long-term memory formation. J. Neurosci. 29:13079-89. pdf (PDF, 1 MB)

Tweedie-Cullen, R.Y., Reck, J.M. and Mansuy I.M. (2009). Comprehensive mapping of post-translational modifications on synaptic, nuclear and histone proteins in the adult mouse brain. J. Prot. Res.8:4966-82.pdf (PDF, 12 MB)

Baumgärtel. K*, Tweedie-Cullen, R.Y.*, Grossmann, J., Gehrig, P., Livingstone-Zatchej, M., Mansuy, I.M. (2009). Changes in the proteome after neuronal Zif268 overexpression. J. Prot. Res. 8:3298-3316. pdf (PDF, 1 MB)

Graeff, J, Mansuy I.M. (2009). Epigenetic dysregulation in cognition disorders. Eur. J. Neurosci. 30:1-8. pdf (PDF, 117 KB)

Saab, B.J., Georgiou, J., Nath, A., Lee, F.J.S., Wang M., Michalon, A., Liu, F., Mansuy, I.M. and Roder, J.C. (2009) NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity and rapid acquisition of spatial memory. Neuron. 63:643-56.pdf (PDF, 1 MB)

Czöndör, K., Ellwanger, K., Fuchs, Y.F., Lutz, S., Gulyás M., Mansuy, I.M., Hausser, A., Pfizenmaier, K., Schlett, K. (2009). Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol. Biol. Cell. 20:2108-20. pdf (PDF, 689 KB)

Haditsch, U., Leone, D.P., Farinelli, M., Chrostek-Grashoff, A., Brakebusch, A., Mansuy, I.M., McConnell, S. K. and Palmer, T. (2009) A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Mol. Cell. Neurosci. 41:409-419.pdf (PDF, 1 MB)

Vicentini. E., Arban. R., E. Angelici, O., Maraia, G., Perico, M., Mugnaini, M., Ugolini, A., Large, C., Domenici, E., Gerrard, P., Bortner, D., Mansuy, I.M., Mangiarini, L., Merlo-Pich, E. (2009). Transient forebrain overexpression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice. Pharm. Biochem. Behav. 93:17-24.pdf (PDF, 359 KB)


Baumgärtel, K., Genoux, D., Welzl, H., Tweedie-Cullen, R.Y., Koshibu, K., Livingstone-Zatchev, M., Mamie, C., Mansuy, I.M. (2008). Control of the establishment of aversive memory by calcineurin and Zif268. Nature. Neurosci. 11:572-578.pdf (PDF, 297 KB)

Hédou, G.F., Koshibu, K. Farinelli, M., Kilic, E., Gee, C. E., Kilic, U., Baumgärtel K., Herman, D., Mansuy I.M. (2008). Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain. J. Neurosci. 28:154-162.pdf (PDF, 576 KB)

Knobloch, M., Mansuy, I.M. (2008). Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol. Neurobiol. 37:73-82.pdf (PDF, 242 KB)

Graeff, J, Mansuy I.M. (2008). Epigenetic codes in cognition and behavior. Brain Behav. Rev. 192:70-87.pdf (PDF, 1 MB)

Jakobsson, J., Coredero, M.I., Bisaz, R., Groner, A.C., Busskamp, V., Bensadoun, J.C., Cammas, F., Losson, R., Mansuy, I.M., Sandi, C., Trono, D. KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress. Neuron. 10:818-831.pdf (PDF, 1 MB)

Papadopoulos, T., Eulenburg, V., Reddy-Alla, S., Mansuy, I.M., Li, Y., Betz, H. Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus. Mol.Cell. Neurosci. 39:161-169.pdf (PDF, 2 MB)

Herzog, C.J., Miot, S., Mansuy, I.M., Dumas, S., Giros, B, Tzavara, E.T. (2008). Chronic valproate normalizes behavior in mice overexpressing calcineurin. Eur. J. Pharmacol. 580:153-160.pdf (PDF, 498 KB)


Munton, R.P.*, Tweedie-Cullen, R.*, Livingstone-Zatchej M.*, Weinandy, F., Waidelich, M., Longo, D., Gehrig, P., Potthast, F., Rutishauser, D., Gerrits, B., Panse, C., Schlapbach, R., Mansuy, I.M. (2007). Qualitative and quantitative analyses of protein phosphorylation in naïve and stimulated mouse synaptosomal preparations. Mol. Cell. Proteomics. 6:283-93.pdf (PDF, 564 KB)

Knobloch, M.*, Farinelli, M.*, Konietzko, U., Nitsch, R.M., Mansuy I.M. (2007). A/beta oligomer-mediated LTP impairment involves PP1-dependent mechanisms. J. Neurosci. 27:7648-7653.pdf (PDF, 424 KB)

Tweedie-Cullen, R.Y., Wollscheid, B., Livingstone-Zatchej, M., Mansuy, I.M. (2007). Neuroproteomics and the detection of regulatory phosphosites. Cur. Proteomics, 4(4), 209-222. pdf (PDF, 3 MB)

Barral, Y, Mansuy I.M. (2007) Septins: Cellular and functional barriers of neuronal activity. Curr. Biol. 17:R961-963.pdf (PDF, 113 KB)

Baumgärtel, K., Fernandez, C., Johansson, T., Mansuy, I.M. (2007). Conditional transgenesis and recombination to study the mechanisms of brain plasticity and memory. Handb. of Exp. Pharmacol. 178:315-45.pdf (PDF, 389 KB)

Shimizu, K., Phan, T. Mansuy I.M., Storm D. R. (2007). Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell. 128:1219-29.pdf (PDF, 870 KB)

Crozatier, C., Farley, S., Mansuy, I.M., Dumas, S., Giros, B, Tzavara, E.T. (2007). Calcineurin (Protein Phosphatase 2B) is involved in the mechanisms of action of antidepressants. Neuroscience. 144:1470-16.pdf (PDF, 367 KB)


Jouvenceau, A., Hédou, G., Potier, B., Kollen, M., Dutar, P. Mansuy, I.M. (2006). Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus. Eur. J. Neurosci. 24, 564-72.pdf (PDF, 1 MB)

Mansuy I.M., and Shenolikar, S. (2006). Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory. Trends Neurosci. 29:679-686.pdf (PDF, 322 KB)


Michalon, A., Koshibu, K., Baumgärtel, K., Spirig, D., Mansuy, I.M. (2005). Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 system. Genesis. 43:205-212.pdf (PDF, 674 KB)

Gee, C., Mansuy, I.M. (2005) Protein phosphatases and their potential implication in neuroprotection. Cell. Mol. Life Sci. 62, 1120-1130.pdf (PDF, 191 KB)

Mansuy, I.M. (2005). Forgetting: Theories and potential mechanisms. Med. Sci. 21:83-88.pdf (PDF, 266 KB)

Yang, Y., Fisher, Q.S., Zhang, Y., Baumgärtel, K., Mansuy, I.M., Daw, N.W. (2005). Reversible blockade of experience-dependent plasticity by calcineurin in the mouse visual cortex. Nat. Neurosci. 8, 791-796.pdf (PDF, 307 KB)

Alagarsamy, S., Saugstad, J., Warren, L., Mansuy, I.M., Gereau, R.W 4th, Conn, P.J. (2005). NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology. 49, 135-145.pdf (PDF, 413 KB)

Biala, G., Betancur, C., Mansuy, I.M., Giros, B. (2005). The reinforcing effects of chronic d-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurin. Eur. J. Neurosci. 21, 3089-3096.pdf (PDF, 187 KB)

Knuesel, I., Elliot, A., Cheng, H.J., Mansuy, I.M., Kennedy, M.B. (2005). A role for Syn-GAP in regulating neuronal apoptosis. Eur. J. Neurosci. 21, 611-621.pdf (PDF, 603 KB)


Mansuy, I.M. (2004). A constraint on cAMP signaling. Neuron.41, 4-6.pdf (PDF, 81 KB)

Munton, R.P., Vizi, S., Mansuy, I.M. (2004). The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity. FEBS Letters 567, 121-128.pdf (PDF, 186 KB)

Hédou G. and Mansuy, I.M. (2004). Inducible molecular switches for the study of long-term potentiation. Long-term Potentiation, Enhancing Neuroscience for 30 Years, Oxford Press.pdf (PDF, 3 MB)


Hédou G. and Mansuy, I.M. (2003). Inducible molecular switches for the study of LTP. Phil. Trans. 358, 797-804.

Mansuy, I.M. (2003). Calcineurin in memory and bidirectional plasticity. Biochem. Biophys. Res. Communic. 311, 1195-1208.

Mansuy, I.M. (2003). Protein phosphatases and memory. Forum Médical Suisse. 31, 727-730.

Wang, J., Liu, S., Haditsch, U., Tu, WH., Cochrane, K., Ahmadian, G., Tran, L., Paw, J., Wang, YT., Mansuy, I.M., Salter, M., and Lu, Y. M. (2003). Interaction of calcineurin and type A GABA Receptor 2 subunits produces long-term depression at CA1 inhibitory synapses. J. Neurosci. 23, 826-836.

Schweizer, C., Balsiger, S., Blüthmann, H., Mansuy, I.M., Fritschy, J.-M., Möhler, H., and Lüscher, B. (2003) The „2 subunit of GABAA receptors is required for maintenance of receptors at mature synapses. Mol. Cell Neurosci. 24, 442-450.


Genoux, D., Haditsch, U., Knobloch, M., Michalon, A., Storm D. and Mansuy, I.M. (2002). The protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418, 970-975.

Mansuy, I.M. (2002). STEPping into position: A new player in the NMDA receptor game. Mol. Interv. 2, 282-284.

Mansuy, I.M.(2002). Behavioral plasticity: from learning to addiction. Curr. Mol. Med. 2, 591-592.


Malleret, G., Haditsch, U., Genoux, D., Jones, M.W., Bliss, T.V.P., Vanhoose, A., M., Weitlauf, C., Kandel, E.R., Winder, D.G. and Mansuy, I.M. (2001). Inducible and reversible enhancement of learning, memory and long-term potentiation by genetic inhibition of calcineurin. Cell 104, 675-686.

Mansuy, I.M. (2001). Les mécanismes cellulaires et moléculaires de l’apprentissage et de la mémoire. Les Prix Nobel de Médecine. Edition Dunes.


Mansuy, I.M. (2000). Molecular cascades to learn and remember. Médecine/Sciences 16, 1296-1297. link

Lu YM, Mansuy IM, Kandel ER, Roder J. (2000) Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. Neuron. 26:197-205.

Mansuy, I.M., Bujard H. (2000)Tetracycline-regulated gene expression in the brain. Curr Opin Neurobiol. 10:593-6.

Mansuy IM, Suter U. (2000) Mouse genetics in cell biology. Exp Physiol. 85:661-79.


Bach, M.E., Barad, M., Son, H., Zhuo, M., Lu, Y.F., Shih, R., Mansuy, I.M., Hawkins, R.D. and Kandel, E.R.  (1999). Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. PNAS 96, 5280-5 link

Zhuo, M., Zhang, W., Son, H., Mansuy, I.M., Sobel, R.A., Seidman, J. and Kandel, E.R. (1999). A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. PNAS 96, 4650-5. link

Mansuy, I.M., Mayford, M, and Kandel, E.R. (1999). Regulated temporal and spatial expression of mutants of CaMKII and calcineurin with the tetracycline-controlled transactivator (tTA) and reverse tTA (rtTA) systems. In Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. Vol. 13. Edited by Crusio W.M., Gerlai R.T. Elsevier. book


Mansuy, I.M., Mayford M, Jacob B, Kandel ER, Bach ME. (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell. 92:39-49.

Winder DG*, Mansuy, I.M.*, Osman M, Moallem TM, Kandel ER. (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell. 92:25-37.

Mansuy, I.M., Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD, Kandel ER. (1998) Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron. 21:257-65.

Mansuy, I.M. (1998). Une approche génétique de la plasticité synaptique et des processus d'apprentissage et de mémoire. Médecine/Sciences 14, 458-452. link


Kojima N, Wang J, Mansuy, I.M., Grant SG, Mayford M, Kandel ER. (1997) Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A. 94:4761-5.

Luthi A, Van der Putten H, Botteri FM, Mansuy, I.M., Meins M, Frey U, Sansig G, Portet C, Schmutz M, Schroeder M, Nitsch C, Laurent JP, Monard D. (1997) Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. J Neurosci. 17:4688-99.

Mayford M, Mansuy, I.M., Muller RU, Kandel ER. (1997) Memory and behavior: a second generation of genetically modified mice. Curr Biol. 7:R580-9.

Mansuy, I.M., van der Putten H, Schmid P, Meins M, Botteri FM, Monard D. Variable and multiple expression of Protease Nexin-1 during mouse organogenesis and nervous system development. Development.119:1119-34.

Botteri, F.M., Mansuy, I.M., Meins, M., Mondadori, C., Sansig, G., Sauer, D., Van der Putten, H. and Monard, D.  (1993).  Expression of glia-derived nexin in transgenic and non-transgenic mice.  Experientia 50, 388.

Botteri, F.M., Mansuy, I.M., Mondadori, C., Sansig, G., Van der Putten, H. and Monard, D.  (1992).  Tissue-specific and high level expression of the glia-derived nexin gene in transgenic mice. Experientia 49, 549.

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