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Brain Research Institute



R. Vighagen, L. Gesuita, A. Damilou, A. Cavaccini, L. Banterle, V. Steenhuis, T. Karayannis (2021) Layer 1 NDNF+ Interneurons Control Bilateral Sensory Processing in a Layer-dependent Manner. bioRxiv  link

Accepted and published

L. Cai, A. Ö. Argunsah, A. Damilou, T. Karayannis (2024) A nasal chemosensation–dependent critical window for somatosensory development. Science link

T. Karayannis (2023) Postnatal Development of the Thalamocortical Circuit and of Sensory-Driven Cortical Activity. The Cerebral Cortex and Thalamus (book chapter) link

T. J. Stachniak, A. Ö. Argunsah, J.-W. Yang, L. Cai, T. Karayannis (2023) Presynaptic kainate receptors onto somatostatin interneurons are recruited by activity throughout development and contribute to cortical sensory adaptation. Journal of Neuroscience link

A. Ö. Argunsah, E. Erdil, MU. Ghani, YR. Cortes, AF. Hobbiss, T. Karayannis, M. Cetin, I. Israely, D. Ünay (2022) An interactive time series image analysis software for dendritic spines. Scientific Reports  link

L. Gesuita, A. Ö. Argunsah, T. Karayannis (2022) Sparse postnatal labeling and quantification of superficial cortical cell synapses in the mouse neocortex. STAR Protocols link

L. Gesuita, A. Cavaccini, A. Ö. Argunsah, E. Favuzzi, L. A. Ibrahim, T. J. Stachniak, M. De Gennaro, S. Utz, Melanie Greter, T. Karayannis (2022) Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. Cell Reports link

L. Cai, J.-W. Yang, C.-F. Wang, S.-J. Chou, H. J. Luhmann, T. Karayannis (2022) Identification of a Developmental Switch in Information Transfer between Whisker S1 and S2 Cortex in Mice. Journal of Neuroscience link bioRxiv  link

T. J. Stachniak*,  R. Kastli*, O. Hanley,  A. Ö Argunsah, E. van der Valk, G. Kanatouris, T. Karayannis (2021) Post-mitotic Prox1 expression controls the final specification of cortical VIP interneuron subtypes. Journal of Neuroscience link (bioRxiv link)

BN. Jaeger, E. Yángüez, L. Gesuita, A. Denoth-Lippuner, M. Kruse, T. Karayannis, S. Jessberger (2020) Miniaturization of Smart-seq2 for high-throughput single-cell and single-nuclei RNA sequencing. STAR Protocols 1, 100081  pdf

N. Frezel, E. Platonova, FF. Voigt, JM. Mateos, R. Kastli, U. Ziegler, T. Karayannis, F. Helmchen, H. Wildner, HU. Zeilhofer (2020) In-depth characterization of layer 5 output neurons of the primary somatosensory cortex innervating the mouse dorsal spinal cord, Cerebral Cortex Communications, in press link

L. Gesuita and T. Karayannis (2020) A “Marginal” Tale: the development of the neocortical layer 1. Current Opinion in Neurobiology link

R. Kastli*, R. Vighagen*, A. van der Bourg*, A. Ö. Argunsah*, A. Iqbal, FF. Voigt, D. Kirschenbau, A. Aguzzi, F. Helmchen. T. Karayannis (2020) Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons. Nature Communications link

A. Iqbal, A. Sheikh, T. Karayannis (2019) DeNeRD: high-throughput detection of neurons for brain-wide analysis with deep learning. Scientific Reports link

A. Iqbal, R. Khan, T. Karayannis (2019) Developing a brain atlas through deep learning. Nature Machine Intelligence, 1.6:

FF. Voigt, D. Kirschenbaum, E. Platonova, S. Pagès, RAA. Campbell, R. Kästli, R. Schaettin, L. Egolf, A. van der Bourg, P. Bethge, K. Haenraets, N. Frézel, T. Topilko, P. Perin, D. Hillier, S. Hildebrand, A. Schueth, A. Roebroeck, B. Roska, E. Stoeckli, R. Pizzala, N. Renier, HU. Zeilhofer, T. Karayannis, U. Ziegler, L. Batti, A. Holtmaat, C. Lüscher, A. Aguzzi, F. Helmchen (2019) The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue. Nature Methods, in press; see also bioRxiv 577122 link

R. Priya, M.F. Paredes, T. Karayannis, N. Yusuf, X. Liu, X. Jaglin, I. Graef, A. Alvarez-Buylla, G. Fishell (2018) Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Reports, 22(7): 1695-1709

G. Miyoshi, A. Young, T. Petros, T. Karayannis, M. McKenzie Chang, A. Lavado, T. Iwano, M. Nakajima, H. Taniguchi, Z.J. Huang, N. Heintz, G. Oliver, F. Matsuzaki, R.P. Machold and G. Fishell (2015) Prox1 regulates the subtype-specific development of caudal ganglionic eminence-derived GABAergic cortical interneurons. J Neuroscience, 35(37): 12869-89

N. De Marco Garcia, R. Priya, S. Tuncdemir, G. Fishell, T. Karayannis (2015) Sensory inputs control the integration of neurogliaform interneurons into cortical circuits. Nature Neuroscience, 18(3):393-401

T. Karayannis*, E. Au*, J. Patel, I. Kruglikov, S. Markx, R. Delorme, D. Héron, J. Glessner, S. Restituito, A. Gordon, L. Rodriguez-Murillo, N.C. Roy, J. Gogos, B. Rudy, M.E. Rice, M. Karayiorgou, H. Hakonarson, B. Keren, G. Huguet, T. Bourgeron, C. Hoeffer, R.W. Tsien, E. Peles, G. Fishell (2014) Cntnap4/Caspr4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission. Nature 511(7508):236-40

E. Au, T. Ahmed, T. Karayannis, S. Biswas, L. Gan, G. Fishell (2013) A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells. Neuron 80(5):1145-58

T. Karayannis* (corresponding), N. De Marco Garcia*, G. Fishell (2012) Functional adaptation of cortical interneurons to attenuated activity is subtype-specific. Frontiers in Neural Circuits 6:66

N. De Marco Garcia*, T. Karayannis*, G. Fishell (2011) Neuronal activity is required for the development of specific cortical interneuron subtypes. Nature, 472(7343):351-5

T. Karayannis*, D. Elfant*, I. Huerta-Ocampo, M. Jones, M. Capogna (2010) Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells. J. Neuroscience, 30(29): 9898-909

T. Karayannis, G. Fishell (2010) Previews. Inhibition as a transplant-mediated therapy: a new paradigm for treating Parkinson's? Cell Stem Cell, 6(3):184-5

P. Fuentealba, T. Klausberger, T. Karayannis, J. Huck, D. Roberts, M. Capogna, P. Somogyi (2010) Expression of COUP-TFII Nuclear Receptor in Restricted GABAergic Neuronal Populations in the Adult Rat Hippocampus. J. Neuroscience, 30(5):1595-609

G.Miyoshi, J. Hjerling-Leffler, T. Karayannis, V.H. Sousa, S.J. Butt, J. Battiste, J. Johnson, R. Machold, G. Fishell (2010) Genetic fate mapping reveals that the CGE produces a large and diverse population of superficial cortical interneurons. J. Neuroscience, 30(5):1582-94

V.H. Sousa, G. Miyoshi, J. Hjerling-Leffler, T. Karayannis, and G. Fishell (2009) Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages. Cerebral Cortex, 19:i1-i10

T. Karayannis, I. Huerta-Ocampo M. Capogna (2007) GABAergic and pyramidal neurons of deep cortical layers directly receive and differently integrate callosal input. Cereb Cortex, 17(5):1213-26

C.J. Price, T. Karayannis, B.Z. Pal, M. Capogna (2005) Group II and III mGlurs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare. Neuropharmacology, 49 Suppl 1:45-56