Open Positions

MSc students

Project title: Assessing mitotic fidelity in human brain organoids

During human cortical development a large number of aneuploid cells may be generated. However, the mechanisms underlying this process remain unexplored. In our laboratory we are using advanced imaging of human forebrain organoids to model this intriguing biological phenomenon. We are looking for a highly motivated student to contribute to this project as their Masters’ thesis.

Main techniques


- Human cell and organoid culture

- Confocal microscopy

- Image analysis using Fiji

- Analysis in R

Timeframe:

Start date: As soon as possible

Duration: At least 6 months, full-time preferred

Requirements:


- Practical experience in the laboratory, ideally previous exposure to cell culture Bachelors’ degree related to cell biology, cancer or development.


Contact details: Please send your CV and motivation letter to Sebastian Jessberger email and Cora Olpe email

 

Project title: Optimising a biosensor of cellular age

Ageing is commonly defined as the time-dependent deterioration in organismal fitness. However, variability in ageing kinetics has led to the hypothesis that each cell type possesses its own ageing trajectory. We currently develop novel ageing biosensors to characterize the progression of cellular age across different murine cell types and tissues. The aim of the project is to modify the existing sensors allowing for real-time analysis of cellular age in diverse cell types using fixed and live-cell imaging.

Techniques and tasks to be performed


- Cloning of new constructs

- Cell culture of mammalian cell lines

- Confocal imaging

- Live-cell imaging

- Immunohistochemistry

- Data analysis (some of it in R studio)

- Lab book maintenance and occasional lab meeting presentations

Project details:

Duration: minimum 6 months, preferably full-time

Starting date: As soon as possible

Requirements:


- Must have bachelor’s degree, preferably with molecular, cellular or biochemical background

- At least 1 wet-lab internship


Contact details: Please send your CV and motivation letter to Sebastian Jessberger email and Margaux Quiniou email

Postdoc positions

We invite applications for Postdoc positions for scientists with an excellent academic track record and previous experience in:


- stem cell biology (using mouse genetics or organoid-based approaches)

- mouse / human genetics and molecular biology

- intravital structural and/or functional imaging


We offer a fantastic research (and living) environment in Zurich and a diverse and highly motivated group of scientists using a variety of approaches and tools to study the molecular and cellular framework of neural stem cell biology in the mouse and human brain.


For more details refer to www.hifo.uzh.ch/en/research/jessberger/interest.html and check out our recent publications.
Please send a motivation letter and CV incl. publication list (and links to pre-prints if applicable) to Sebastian Jessberger email