Project title: Using a sensor of cellular age to track neural stem cell aging
Project background: We have developed an age-sensor that translates cellular age into measurable fluorescence. The aim of this project is to use this age-sensor to track how neural stem cells age over time when overexpressing toxic proteins.
- Express the age-sensor in neural stem cells
- Induce expression of toxic proteins
- Perform live-cell imaging with neural stem cells and track their aging rate
- Correlate the sensor signal with aging markers
Techniques and tasks to be performed
- Cell culture of mammalian cell lines
- Confocal imaging
- Live-cell imaging
- Data analysis (mostly with FIJI but also some in R studio)
- Lab book maintenance and occasional lab meeting presentations
Duration: minimum 5 months, preferably full-time
Starting date: TBD
- Must have bachelor’s degree, preferably with molecular, cellular or biochemical background
- At least 1 wet-lab internship
We invite applications for Postdoc positions for scientists with an excellent academic track record and previous experience in:
- stem cell biology (using mouse genetics or organoid-based approaches)
- mouse / human genetics and molecular biology
- intravital structural and/or functional imaging
We offer a fantastic research (and living) environment in Zurich and a diverse and highly motivated group of scientists using a variety of approaches and tools to study the molecular and cellular framework of neural stem cell biology in the mouse and human brain.
For more details refer to www.hifo.uzh.ch/en/research/jessberger/interest.html and check out our recent publications.
Please send a motivation letter and CV incl. publication list (and links to pre-prints if applicable) to Sebastian Jessberger email