Open Positions

Project title: Using a sensor of cellular age to track neural stem cell aging

Project background: We have developed an age-sensor that translates cellular age into measurable fluorescence. The aim of this project is to use this age-sensor to track how neural stem cells age over time when overexpressing toxic proteins.

Goals

- Express the age-sensor in neural stem cells

- Induce expression of toxic proteins

- Perform live-cell imaging with neural stem cells and track their aging rate

- Correlate the sensor signal with aging markers

Techniques and tasks to be performed

- Cell culture of mammalian cell lines

- Confocal imaging

- Live-cell imaging

- Immunohistochemistry

- Data analysis (mostly with FIJI but also some in R studio)

- Lab book maintenance and occasional lab meeting presentations

Project details:

Duration: minimum 5 months, preferably full-time

Starting date: TBD

Requirements:

- Must have bachelor’s degree, preferably with molecular, cellular or biochemical background

- At least 1 wet-lab internship

Contact details: Please send your CV and motivation letter to Sebastian Jessberger email and Margaux Quiniou email

We invite applications for Postdoc positions for scientists with an excellent academic track record and previous experience in:

- stem cell biology (using mouse genetics or organoid-based approaches)

- mouse / human genetics and molecular biology

- intravital structural and/or functional imaging

We offer a fantastic research (and living) environment in Zurich and a diverse and highly motivated group of scientists using a variety of approaches and tools to study the molecular and cellular framework of neural stem cell biology in the mouse and human brain.

For more details refer to www.hifo.uzh.ch/en/research/jessberger/interest.html and check out our recent publications.
Please send a motivation letter and CV incl. publication list (and links to pre-prints if applicable) to Sebastian Jessberger email