Project title: Optimising a biosensor of cellular age

Ageing is commonly defined as the time-dependent deterioration in organismal fitness. However, variability in ageing kinetics has led to the hypothesis that each cell type possesses its own ageing trajectory. We currently develop novel ageing biosensors to characterize the progression of cellular age across different murine cell types and tissues. The aim of the project is to modify the existing sensors allowing for real-time analysis of cellular age in diverse cell types using fixed and live-cell imaging.

Techniques and tasks to be performed

- Cloning of new constructs

- Cell culture of mammalian cell lines

- Confocal imaging

- Live-cell imaging

- Immunohistochemistry

- Data analysis (some of it in R studio)

- Lab book maintenance and occasional lab meeting presentations

Project details:

Duration: minimum 6 months, preferably full-time

Starting date: As soon as possible

Requirements:

- Must have bachelor’s degree, preferably with molecular, cellular or biochemical background

- At least 1 wet-lab internship

Contact details: Please send your CV and motivation letter to Sebastian Jessberger email and Margaux Quiniou email

We invite applications for Postdoc positions for scientists with an excellent academic track record and previous experience in:

- stem cell biology (using mouse genetics or organoid-based approaches)

- mouse / human genetics and molecular biology

- intravital structural and/or functional imaging

We offer a fantastic research (and living) environment in Zurich and a diverse and highly motivated group of scientists using a variety of approaches and tools to study the molecular and cellular framework of neural stem cell biology in the mouse and human brain.

For more details refer to www.hifo.uzh.ch/en/research/jessberger/interest.html and check out our recent publications.
Please send a motivation letter and CV incl. publication list (and links to pre-prints if applicable) to Sebastian Jessberger email